The RET gene was first identified in 1985 by transfection of NIH/3T3 fibroblast cells with human lymphoma DNA. The transformed NIH/3T3 cells proved to harbor a fusion gene , which was absent in the original tumor.this fusion gene contained part of a gene that encoded a tyrosine kinase domain, and that gene from which the tyrosine kinase domain was part was thereafter called RET.
RET is localized on chromosome 10 and contains 21 exons.
REarranged during Transfection (RET) gene encodes a receptor tyrosin kinase that has an important role in many essential processes of cells.
Gain of function mutation in RET stimulates proliferation and blocks apoptosis.

پژوهشکده علوم

غدد درون ریز و متابولیسم

و قطب علمی بیماری های غدد درون ریز

تهران، بزرگراه شهيد چمران، ولنجک، خ يمن، ابتداي خيابان شهید اعرابی، پلاک 24، پژوهشکده علوم غدد درون ريز و متابوليسم

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